Immune Defense Clinical Studies

Immune System Support

  1. Alzheimer's disease and disseminated mycoses, https://pubmed.ncbi.nlm.nih.gov/24452965/
  2. Anti-stress action of an orally-given combination of resveratrol, β-glucan, and vitamin C; https://pubmed.ncbi.nlm.nih.gov/25255758/
  3. Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise; https://pubmed.ncbi.nlm.nih.gov/23927572/
  4. Baker's yeast protects against fatal infections; Date: August 10, 2011, Source: Society for General Microbiology
  5. Bakers yeast, and their extracts, have been given a GRAS (Generally Recognized as Safe) rating. This is one of the highest safety rating a substance can achieve. The specifications for this rating can be found in Code of Federal Regulations: 21CFR184.1983 -- Sec. 184.1983.
  6. Dectin-1 Activation Controls Maturation of β-1,3-Glucancontaining Phagosomes*; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668760/
  7. Dectin-1 Stimulation Selectively Reinforces LPS-driven IgG1 Production by Mouse B Cells; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817302/
  8. Effects of dietary β-glucans supplementation on cytokine expression in porcine liver; https://pubmed.ncbi.nlm.nih.gov/23365278/
  9. Effects of orally administered yeast-derived beta-glucans: a review; https://pubmed.ncbi.nlm.nih.gov/24019098/
  10. Fungal β-glucan, a Dectin-1 ligand, promotes protection from type 1 diabetes by inducing regulatory innate immune response; https://pubmed.ncbi.nlm.nih.gov/25143443/
  11. Immune-modulatory effects of dietary Yeast Beta-1,3/1,6-D-glucan; https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-13-38
  12. In vitro effects of Candida albicans and Aspergillus fumigatus on dendritic cells and the role of beta glucan in this effect; https://pubmed.ncbi.nlm.nih.gov/24595999/
  13. Induction of Innate Immune Response through Toll-like Receptor 2 and Dectin 1 prevents type 1 diabetes1; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679699/
  14. Innate immune recognition of microbial cell wall components and microbial strategies to evade such recognitions; https://www.sciencedirect.com/science/article/pii/S0944501313000207?via%3Dihub
  15. Stimulation with the Aureobasidium pullulans-produced β-glucan effectively induces interferon stimulated genes in macrophage-like cell lines; https://www.nature.com/articles/srep04777
  16. The Effects of β – Glucan on Fish Immunity; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842698/
  17. β-Glucan enhances antitumor immune responses by regulating differentiation and function of monocytic myeloid-derived suppressor cells; https://pubmed.ncbi.nlm.nih.gov/23424024/

Anti-Inflammatory Support

  1. 1,3-β-glucan affects the balance of Th1/Th2 cytokines by promoting secretion of anti-inflammatory cytokines in vitro; https://pubmed.ncbi.nlm.nih.gov/23799616/
  2. Beta-glucan attenuates inflammatory cytokine release and prevents acute lung injury in an experimental model of sepsis; https://pubmed.ncbi.nlm.nih.gov/17414422/
  3. Efficacy of caspofungin, a 1,3-β-D-glucan synthase inhibitor, on Pneumocystis carinii pneumonia in rats; https://pubmed.ncbi.nlm.nih.gov/25288652/
  4. Glucan-immunostimulant, adjuvant, potential drug; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095473/
  5. Human intestinal epithelial cells respond to β-glucans via Dectin-1 and Syk; https://pubmed.ncbi.nlm.nih.gov/25251945/
  6. Rat adipose tissue-derived stem cells attenuate peritoneal injuries in rat zymosan-induced peritonitis accompanied by complement activation; https://pubmed.ncbi.nlm.nih.gov/24364907/
  7. β-Glucan attenuates inflammatory responses in oxidized LDL-induced THP-1 cells via the p38 MAPK pathway; https://pubmed.ncbi.nlm.nih.gov/24418375/

Blood Glucose Support

  1. (1→3)-β-D-Glucan reduces the damages caused by reactive oxygen species induced in human platelets by lipopolysaccharides; https://pubmed.ncbi.nlm.nih.gov/23911506/
  2. An immunopotentiator of beta-1,6;1,3 D-glucan prevents diabetes and insulitis in BB rats; https://pubmed.ncbi.nlm.nih.gov/1425150/
  3. Beta-glucans in the treatment of diabetes and associated cardiovascular risks; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663451/
  4. Depression of the glycemic index by high levels of beta-glucan fiber in two functional foods tested in type 2 diabetes; https://pubmed.ncbi.nlm.nih.gov/12080401/
  5. [Dietary fibers: current trends and health benefits in the metabolic syndrome and type 2 diabetes]; https://pubmed.ncbi.nlm.nih.gov/19768242/
  6. Fungal β-glucan, a Dectin-1 ligand, promotes protection from type 1 diabetes by inducing regulatory innate immune response; https://pubmed.ncbi.nlm.nih.gov/25143443/
  7. Hypoglycemic activity of polysaccharide fractions containing beta-glucans from extracts of Rhynchelytrum repens (Willd.) C.E. Hubb., Poaceae; https://pubmed.ncbi.nlm.nih.gov/15933782/
  8. Hypoglycemic and Hypocholesterolemic Effects of Botryosphaeran from Botryosphaeria rhodina MAMB-05 in Diabetes-Induced and Hyperlipidemia Conditions in Rats; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385115/
  9. Induction of Innate Immune Response through Toll-like Receptor 2 and Dectin 1 prevents type 1 diabetes1; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679699/
  10. Potential effects of nichi glucan as a food supplement for diabetes mellitus and hyperlipidemia: preliminary findings from the study on three patients from India; https://pubmed.ncbi.nlm.nih.gov/23304164/
  11. Preparation, characterization, and biological properties of β-glucans; https://pubmed.ncbi.nlm.nih.gov/22171300/
  12. Roles for TGF-β and Programmed Cell Death 1 Ligand 1 in Regulatory T Cell Expansion and Diabetes Suppression by Zymosan in Nonobese Diabetic Mice; https://www.jimmunol.org/content/185/5/2754
  13. Synergic effects of bitter melon and β-Glucan composition on STZ-induced rat diabetes and its complications; https://pubmed.ncbi.nlm.nih.gov/22297232/